11–12 Jul 2024
UniPA SAAF
Europe/Rome timezone
Innovations For Sustainable Crop Production In The Mediterranean Region

Nutrition, epigenetic modulation and healthy ageing

Not scheduled
20m
Aula Magna "G.P. Ballatore" (UniPA SAAF)

Aula Magna "G.P. Ballatore"

UniPA SAAF

Oral Presentation Topic 3. Food and Health: How the research of Well-being passes through the Agri-food Production System Sessione 3

Speaker

Giuseppe Passarino (Dipartimento di Biologia Ecologia e Scienze della Terra, Università della Calabria)

Description

Calorie restriction has shown to be able to extend lifespan in model organisms. Recent epidemiological studies have indicated that similar results can be obtained in humans, without the side effects of calorie restriction, by means of a low animal-protein diet before 65 years of age. The analysis of numerous methylation sites has shown that it is possible to calculate the biological age of a subject and, consequently, to evaluate the rate of ageing. On the other hand, several epigenetic studies have demonstrated the plasticity of the tissue specific methylation profile. In particular, changes in the DNA methylation status have been reported to be among the mechanisms by which age and nutrition intersect each other and, in turn, influence the aging plasticity. On the ground of these results, new analyses have been planned in order to find out the correlation between nutrition and epigenetic variation in order to define the genomic regions which are affected by calorie restriction and/or analogous diet strategies. This may lead to explore the possibility to modulate these epigenetic sites to obtain a deceleration of ageing.

Primary author

Giuseppe Passarino (Dipartimento di Biologia Ecologia e Scienze della Terra, Università della Calabria)

Presentation materials

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